教学科研

施琳

发布日期:2019-09-25     作者:      分享到:

施琳(1988.08-),2017年获瑞典农业科学大学博士学位,2018年入职瑞典查尔莫斯理工大学开展博士后研究工作,2019年入职澳门威斯人7026com,副研究员。主要研究围绕精准营养研究热点,开展以代谢组学、转录组学、16s/宏基因组测序分析以及组学融合技术为基础的人群队列和饮食干预研究,探索膳食营养改善健康作用及生物学机制。在具有国际影响力的食品营养、医学和生物统计领域期刊上发表多篇学术论文,包括Nature CommunicationsJournal of Internal MedicineAmerican Journal of Clinical NutritionBioinformatics担任中国营养学会营养与代谢分会委员、中国营养学会传统食养与食疗药膳专业学组委员、陕西省饮食营养协会第二届理事、西安交通大学全球健康研究院人类营养与代谢实验室共同主任,期刊Food Frontiers编委,以及American Journal of Clinical NutritionMolecular Nutrition & Food ResearchMetabolomics, Nutrition & Metabolism等国际期刊审稿人。

联系方式:

邮箱:linshi198808@snnu.edu.cn

QQ554853024

主持/参与的科研项目:

1. 国家自然科学青年科学基金项目,麦麸膳食纤维对肠道菌群代谢色氨酸产生吲哚丙酸的调控作用及机制研究,24万,主持。

2. 瑞典国家研究委员FORMAS基金,A novel personalized nutrition strategy for improved health through precision prevention of non-communicable diseases300万瑞典克朗,联合主持(中方唯一负责人,2/2)

3. 中央高校基本科研业务费专项资金多组学融合策略研究滇黄精改善营养性肥胖小鼠肠道微生态及其免疫功能分子机制,5万,主持。

4. 西部果品资源高值利用教育部工程研究中心开放课题,果蔬尾菜膳食纤维精准益生营养功能初探,2万,主持。

5. 陕西省国际科技合作基地中俄食品与健康科学国际联合研究中心开放课题,组学融合策略探究不同方法炮制滇黄精品预防高脂诱导小鼠糖脂代谢紊乱机制, 6万,主持

6. 陕西省科技厅重点研发计划项目-重点产业创新链(群)(社发领域),肠菌群代谢物琥珀酸介导功能糖精准营养干预II型糖尿病的关键技术,80万,参加。

7. 瑞典国家研究委员Vetenskapsrådet-medicine基金,Swedish Infrastructure for Medical Population-based Life-course and Environment Research5500万瑞典克朗,参加。

代表性学术论文

* Corresponding author; # Equal contribution

1. Bo Ren#, Luanfeng Wang#, Lin Shi, Xin Jin, Yan Liu, Rui Hai Liu, Fei Yin,

Enrique Cadenas, Xiaoshuang Dai, Zhigang Liu*, Xuebo LiuMethionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21, Redox Biology, 2021;41,101940.

2. Jie Kang, Di Wang, Duan-yong Chang, Lin Zhai, Lin Shi *, Fei Guo *. Aerobic exercise prevents depression via alleviating hippocampus injury in chronic stressed depression rats, Brain sciences, 2021, 11(1):9.

3. Yongchang Duan#, Lin Shi#, Zheng Jin, Meng Hu, Hao Huang, Tao Yan, Kunru ZhangSwimming exercise ameliorates hypertension-induced kidney dysfunction via alleviating renal interstitial fibrosis and apoptosis,Kidney and Blood Pressure Research2021,In Press.

4. Demir Djekic#, Lin Shi#,*, Fredrik Calais, Frida Carlsson, Rikard Landberg, Tuulia Hyötyläinen, Ole Frøbert. Effects of a lacto-ovo-vegetarian diet on the plasma lipidome and its association with atherosclerotic burden in patients with coronary artery disease-a randomized, open-label, cross-over study, Nutrients. 2020;12(11):3586.

5. Djekic D#, Shi L#, Brolin H, Carlsson F, Särnqvist C, Savolainen O, Cao Y, Bäckhed F, Tremaroli V, Landberg R, Frøbert O. Effects of a vegetarian diet on cardiometabolic risk factors, gut microbiota, and plasma metabolome in subjects with ischemic heart disease - a randomized, cross-over study, Journal of the American Heart Association. 2020;9(18):e016518.

6. T. Schillemans*, L. Shi, C. Donat-Vargas, K. Hanhineva, A. Tornevi, I. Johansson, J. Koponen, H. Kiviranta, O. Rolandsson, I.A. Bergdahl, R. Landberg, A. Åkesson, C. Brunius. Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – a nested case-control study, Environment International.2020; 146:106180.

7. Yang M, Yan T, Yu M, Kang J, Gao R, Wang P, Zhang Y, Zhang H, Shi L*. Advances in understanding of health-promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics. Food Frontiers. 2020;1–22.

8. Liu Z, Dai X, Zhang H, Shi R, Hui Y, Jin X, Zhang W, Wang L, Wang Q, Wang D, Wang J, Tan X, Ren B, Liu X, Zhao T, Wang J, Pan J, Yuan T, Chu C, Lan L, Yin F, Cadenas E, Shi L*, Zhao S*, Liu X*. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment, Nat Commun 2020; 11(1): 855.

9. Shi L, Brunius C, Johansson I, Bergdahl IA, Rolandsson O, van Guelpen B, Winkvist A, Hanhineva K, Landberg R. Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk, Journal of internal medicine 2020; 287(4): 405-421.

10. Liu X #, Shi L #, Dai X, Chen H, Zhang C, Wang P, Wu Q, Zeng L, Yan H. Plasma metabolites mediate the association of coarse grain intake with blood pressure in hypertension –free adults, Nutrition, Metabolism and Cardiovascular Diseases;2020; 30(9):1512-1519.

11. Palmnäs M, Brunius C, Shi L, Rostgaard-Hansen A, Torres NE, González-Domínguez R, Zamora-Ros R, Ye YL, Halkjær J, Tjønneland A, Riccardi G, Giacco R, Costabile G, Vetrani C, Nielsen J, Andres-Lacueva C, Landberg R. Perspective: Metabotyping—A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease, Advances in nutrition 2019; 11(3): 524-532.

12. Schillemans T #, Shi L #, Liu X, Åkesson A, Landberg R, Brunius C. Visualization and Interpretation of Multivariate Associations with Disease Risk Markers and Disease Risk—The Triplot, Metabolites 2019; 9: 133.

13. Shi L, Brunius C, Bergdahl IA, Johansson I, Rolandsson O, Donat Vargas C, Kiviranta H, Hanhineva K, Åkesson A, Landberg R. Joint analysis of metabolite markers of fish intake and persistent organic pollutants in relation to type 2 diabetes risk in swedish adults, Journal of nutrition 2019; 149(8): 1413-1423.

14. Shi L, Brunius C, Johansson I, Bergdahl IA, Lindahl B, Hanhineva K, Landberg R. Plasma metabolites associated with healthy Nordic dietary indexes and risk of type 2 diabetes—a nested case-control study in a Swedish population, The American Journal of Clinical Nutrition 2018; 108(3): 564-575.

15. Shi L, Westerhuis JA, Rosén J, Landberg R, Brunius C. Variable selection and validation in multivariate modelling, Bioinformatics 2018; 35(6): 972-980.

16. Shi L, Brunius C, Lehtonen M, Auriola S, Bergdahl IA, Rolandsson O, Hanhineva K, Landberg R. Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort, Diabetologia 2018; 61(4): 849-861.

17. Shi L, Brunius C, Lindelof M, Shameh SA, Wu H, Lee I, Landberg R, Moazzami AA. Targeted metabolomics reveals differences in the extended postprandial plasma metabolome of healthy subjects after intake of whole-grain rye porridges versus refined wheat bread, Molecular nutrition & food research 2017; 61(7).

18. Shi L, Brunius C, Lindelof M, Shameh SA, Wu H, Lee I, Landberg R, Moazzami AA. Targeted metabolomics reveals differences in the extended postprandial plasma metabolome of healthy subjects after intake of whole-grain rye porridges versus refined wheat bread, Molecular nutrition & food research 2017; 61(7).

19. Lee I, Shi L, Webb D-L, Hellström PM, Risérus U, Landberg R. Effects of whole-grain rye porridge with added inulin and wheat gluten on appetite, gut fermentation and postprandial glucose metabolism: a randomised, cross-over, breakfast study, British Journal of Nutrition 2017; 116(12): 2139-2149.

20. Brunius C, Shi L, Landberg R. Large-scale untargeted LC-MS metabolomics data correction using between-batch feature alignment and cluster-based within-batch signal intensity drift correction, Metabolomics : Official journal of the Metabolomic Society 2016; 12(11): 173.